Dr. Marcus Guimaraes wrote this essential book to demystify depression, a widely misunderstood condition affecting millions globally. Often dismissed as "weakness" or "temporary sadness," depression is actually a complex neurobiological disorder with concrete physical foundations. The book begins with detailed brain anatomy, explaining how structures like the hippocampus, amygdala, and prefrontal cortex contribute to depression. This scientific foundation validates patients' experiences by demonstrating real chemical and physical brain changes, proving it's not about "lack of willpower." Dr. Guimaraes thoroughly characterizes different depression types: major depression, dysthymia, seasonal depression, postpartum depression, and bipolar disorder. Each form has unique symptoms and requires specific therapeutic approaches, helping readers identify their condition accurately. The comprehensive treatment section covers both medication and non-pharmaceutical interventions. Beyond explaining how antidepressants work and their side effects, the book emphasizes two powerful non-medicinal approaches: regular exercise and Viktor Frankl's logotherapy. The exercise chapter details how physical activity releases mood-improving neurotransmitters, reduces brain inflammation, and promotes neurogenesis, offering adaptable sports modalities for various depression levels.